bremelanotide

Ligand id: 10408

Name: bremelanotide

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Peptide or derivative
Approved drug? Yes (FDA (2019))
IUPAC Name
(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxylic acid
International Nonproprietary Names
INN number INN
8737 bremelanotide
Synonyms
PT-141 | PT141 | Vyleesi®
Comments
Bremelanotide is a stabilised, cyclic derivative of αMSH. Although it exhibits little selectivity across the melanocortin receptor family (with the exception of MC2, the ACTH receptor), bremelanotide's ability to increase female sexual arousal/desire is attributed primarily to agonist activity at the MC3 and MC4 receptors [2].
HELM annotation is PEPTIDE1{[ac].[Nle].D.H.[dF].R.W.K}$PEPTIDE1,PEPTIDE1,3:R3-8:R3$$$.
Database Links
BindingDB Ligand 50389769
CAS Registry No. 189691-06-3 (source: WHO INN record)
ChEMBL Ligand CHEMBL2070241
DrugBank Ligand DB11653
PubChem CID 9941379
Search Google for chemical match using the InChIKey FFHBJDQSGDNCIV-MFVUMRCOSA-N
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Search UniChem for chemical match using the InChIKey FFHBJDQSGDNCIV-MFVUMRCOSA-N
Search UniChem for chemicals with the same backbone FFHBJDQSGDNCIV
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